BDBM50606291 CHEMBL5196650::US20230287003, Example 13e

SMILES C[C@@H]1C[C@H](O)CN(C1)c1ncc(Cl)c(Nc2ccc3n(C)c(=O)c4OCC(F)(F)[C@@H](Nc4c3c2)C2CC2)n1

InChI Key InChIKey=GSGDUDAFETZSPM-DHZVRSILSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50606291   

TargetB-cell lymphoma 6 protein(Homo sapiens)
Cancer Research Technology

US Patent
LigandPNGBDBM50606291(CHEMBL5196650 | US20230287003, Example 13e)
Affinity DataIC50:  2.51nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB-cell lymphoma 6 protein(Homo sapiens)
Cancer Research Technology

US Patent
LigandPNGBDBM50606291(CHEMBL5196650 | US20230287003, Example 13e)
Affinity DataEC50: >2.00E+3nMAssay Description:Degradation of BCL6 in human KARPAS-422 cells by MSD assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
Cancer Research Technology

US Patent
LigandPNGBDBM50606291(CHEMBL5196650 | US20230287003, Example 13e)
Affinity DataEC50: >2.00E+3nMAssay Description:Degradation of BCL6 in human OCI-Ly1 cells incubated for 2 hrs by MSD assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
Cancer Research Technology

US Patent
LigandPNGBDBM50606291(CHEMBL5196650 | US20230287003, Example 13e)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of N-terminal thioredoxin-His6 tagged human BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI incubated for 2 hrs ...More data for this Ligand-Target Pair
In DepthDetails PubMed