BDBM50607314 CHEMBL5219349

SMILES Cc1ccccc1Oc1cc(-n2c(=O)cc([nH]c2=O)C(F)(F)F)c2ccccc2c1C#N

InChI Key InChIKey=JBKRLZPXWNTYBD-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50607314   

TargetBranched-chain-amino-acid aminotransferase, cytosolic(Homo sapiens (Human))
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50607314(CHEMBL5219349)
Affinity DataIC50:  70nMAssay Description:Inhibition of N-terminal his-tagged human recombinant BCAT1 expressed in Escherichia coli BL21(DE3) cells using leucine and alpha-KG as substrate in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBranched-chain-amino-acid aminotransferase, cytosolic(Homo sapiens (Human))
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50607314(CHEMBL5219349)
Affinity DataIC50:  70nMAssay Description:Inhibition of N-terminal his-tagged human recombinant BCAT1 expressed in Escherichia coli BL21(DE3) cells using leucine and alpha-KG as substrate in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50607314(CHEMBL5219349)
Affinity DataIC50:  290nMAssay Description:Inhibition of human recombinant BCAT2 using leucine and alpha-KG as substrate in presence of NADH by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50607314(CHEMBL5219349)
Affinity DataIC50:  270nMAssay Description:Inhibition of human recombinant BCAT2 using leucine and alpha-KG as substrate in presence of NADH by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50607314(CHEMBL5219349)
Affinity DataIC50:  290nMAssay Description:Inhibition of human recombinant BCAT2 using leucine and alpha-KG as substrate in presence of NADH by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetBranched-chain-amino-acid aminotransferase, cytosolic(Homo sapiens (Human))
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50607314(CHEMBL5219349)
Affinity DataIC50:  90nMAssay Description:Inhibition of N-terminal his-tagged human recombinant BCAT1 expressed in Escherichia coli BL21(DE3) cells using leucine and alpha-KG as substrate in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB