BDBM50607924 CHEMBL5278864

SMILES NC(=O)C(=C/c1cccc(c1)-c1ncnc2[nH]ccc12)\C#N

InChI Key InChIKey=PBACTZXZNFJQGT-GHXNOFRVSA-N

Data  6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50607924   

TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))TBA

LigandBDBM50607924(CHEMBL5278864)Copy SMILESCopy InChI

Affinity DataIC50:  399nMAssay Description:Inhibition of RSK2 (unknown origin) at 100 uM preincubated for 1 hr followed by substrate addition and measured after 1 hr by Z-lyte assay relative t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))TBA

LigandBDBM50607924(CHEMBL5278864)Copy SMILESCopy InChI

Affinity DataIC50:  281nMAssay Description:Inhibition of MAP2K4 (unknown origin) at 100 uM preincubated for 1 hr followed by substrate addition and measured after 1 hr by Z-lyte assay relative...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))TBA

LigandBDBM50607924(CHEMBL5278864)Copy SMILESCopy InChI

Affinity DataIC50:  26nMAssay Description:Inhibition of MELK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
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B.MOADantibodypediaGoogleScholar

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TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA

LigandBDBM50607924(CHEMBL5278864)Copy SMILESCopy InChI

Affinity DataIC50:  0.770nMAssay Description:Inhibition of JAK3 (unknown origin) incubated for 45 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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Ligand Info

In DepthDetails PubMed
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TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA

LigandBDBM50607924(CHEMBL5278864)Copy SMILESCopy InChI

Affinity DataIC50:  0.770nMAssay Description:Inhibition of JAK3 (unknown origin) preincubated for 1 hr followed by substrate addition and measured after 1 hr by Z-lyte assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand Info

In DepthDetails PubMed
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TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA

LigandBDBM50607924(CHEMBL5278864)Copy SMILESCopy InChI

Affinity DataIC50:  56nMAssay Description:Inhibition of JAK3 (unknown origin) incubated for 45 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand Info

In DepthDetails PubMed
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