BDBM50614127 CHEMBL5267043

SMILES CC(=O)N1c2cnc(NC(=O)OCC3(CC3)C(F)(F)F)nc2C2(CCC(F)(F)CC2)C1(C)C

InChI Key InChIKey=XEGSXAZIAWXAJO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50614127   

TargetThyrotropin receptor(Rattus norvegicus)TBA
LigandPNGBDBM50614127(CHEMBL5267043)
Affinity DataIC50:  48nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetFollicle-stimulating hormone receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614127(CHEMBL5267043)
Affinity DataIC50:  156nMAssay Description:Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614127(CHEMBL5267043)
Affinity DataIC50:  33nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed