BDBM506382 US11045455, Compound 31

SMILES CC1(CC1)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12

InChI Key InChIKey=KLSXACKMKSRIDU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 506382   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM506382(US11045455, Compound 31)
Affinity DataIC50:  0.720nMAssay Description:1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM506382(US11045455, Compound 31)
Affinity DataIC50: >3.00E+4nMAssay Description:The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM506382(US11045455, Compound 31)
Affinity DataIC50:  23.6nMAssay Description:1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM506382(US11045455, Compound 31)
Affinity DataIC50:  1.23nMAssay Description:1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent