BDBM506394 US11045455, Compound 48
SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(c(Cl)n1)-c1ccnc2[nH]ccc12
InChI Key InChIKey=LVYKJFMGPICBJK-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 506394
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Affinity DataIC50: 5.66nMAssay Description:1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Affinity DataIC50: 1.40nMAssay Description:1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Affinity DataIC50: >3.00E+4nMAssay Description:The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...More data for this Ligand-Target Pair