BDBM508378 7-chloro-5-fluoro-4-(((1r,3r)-3- methoxy-cyclobutyl)amino)-1-(o- tolyl)quinazolin-2(1H)-one::US11046691, Compound 689::US11084798, Cpd No 689::US11130759, Cpd. No. 689
SMILES CO[C@H]1CC(C1)Nc1nc(=O)n(-c2ccccc2C)c2cc(Cl)cc(OC)c12
InChI Key InChIKey=BEQFILSMQQQBCO-ZVGHLENZSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 508378
Affinity DataIC50: <200nMAssay Description:MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...More data for this Ligand-Target Pair
Affinity DataIC50: <200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
Affinity DataIC50: <200nMAssay Description:For the assay, a mixture of 1 mM L-methionine/1 mM ATP (2× final pre-stopped concentration) in assay buffer; MAT2A (2× final pre-stopped concentratio...More data for this Ligand-Target Pair