BDBM508712 (R or S)-2,2-difluoro-8-(1-pyrimidin- 5-ylpiperidin-3-yl)[1,3]dioxolo[4,5- h][1,2,4]triazolo[1,5-c]quinazolin-5- amine (faster eluting b)::US11046714, Example 146

SMILES Nc1nc2c3OC(F)(F)Oc3ccc2c2nc(nn12)[C@H]1CCCN(C1)c1cncnc1

InChI Key InChIKey=JJESMNPJLANBMC-JTQLQIEISA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 508712   

TargetAdenosine receptor A2a(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM508712((R or S)-2,2-difluoro-8-(1-pyrimidin- 5-ylpiperidi...)
Affinity DataKi:  44nMAssay Description:The following table shows representative data for the compounds of the Examples as A2a receptor antagonists as determined by a competition binding as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent