BDBM510968 7-cyclopropyl-6-(2- hydroxy-2- methylpropoxy)-N-[(4s)-6- ({5-carbamoyl-1-methyl- 1H-pyrazolo[3,4-b]pyridin- 6-yl}oxy)spiro[3.3]heptan- 2-yl]pyrazolo[1,5- a]pyridine-3-carboxamide::US11078197, Example 147::US11673886, Example 147

SMILES Cn1ncc2cc(C(N)=O)c(O[C@H]3C[C@@]4(C[C@@H](C4)NC(=O)c4cnn5c(C6CC6)c(OCC(C)(C)O)ccc45)C3)nc12

InChI Key InChIKey=NLRBPNTWMCGZBF-SZUZZLPFSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510968   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510968(7-cyclopropyl-6-(2- hydroxy-2- methylpropoxy)-N-[(...)
Affinity DataIC50:  2.90nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510968(7-cyclopropyl-6-(2- hydroxy-2- methylpropoxy)-N-[(...)
Affinity DataIC50:  2.90E+3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent