BDBM511617 US11059801, Compound dBET25
SMILES COC(=O)C[C@@H]1N=C(c2c(sc(C)c2C(=O)NCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)-n2c(C)nnc12)c1ccc(Cl)cc1
InChI Key InChIKey=CTQCRJBAHKVGBK-SKCDSABHSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 511617
TargetBromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Dana-Farber Cancer Institute
US Patent
Dana-Farber Cancer Institute
US Patent
Affinity DataIC50: 182nMAssay Description:AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...More data for this Ligand-Target Pair