BDBM511617 US11059801, Compound dBET25

SMILES COC(=O)C[C@@H]1N=C(c2c(sc(C)c2C(=O)NCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)-n2c(C)nnc12)c1ccc(Cl)cc1

InChI Key InChIKey=CTQCRJBAHKVGBK-SKCDSABHSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 511617   

TargetBromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM511617(US11059801, Compound dBET25)
Affinity DataIC50:  182nMAssay Description:AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent