BDBM511628 US11059801, Compound dBET36
SMILES Cc1nnc2[C@H](CC(=O)NCCCCNC(=O)Cc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
InChI Key InChIKey=BFZZIGPNZLXGRV-QBHOUYDASA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 511628
TargetBromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Dana-Farber Cancer Institute
US Patent
Dana-Farber Cancer Institute
US Patent
Affinity DataIC50: 80.3nMAssay Description:AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...More data for this Ligand-Target Pair