BDBM511632 US11059801, Compound dBET41
SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCc1ccc(CNC(=O)COc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)cc1)c1nnc(C)n-21)c1ccc(Cl)cc1
InChI Key InChIKey=ODYIWGILJYUPOR-UFXYQILXSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 511632
TargetBromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon(Homo sapiens (Human))
Dana-Farber Cancer Institute
US Patent
Dana-Farber Cancer Institute
US Patent
Affinity DataIC50: 62.8nMAssay Description:AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...More data for this Ligand-Target Pair