BDBM514522 6,6-dimethyl-8-(7- (trifluoromethyl)imidazo[1,5- a]pyridin-5-yl)-1,3,8- triazaspiro[4.5]decane-2,4- dione::US11096930, Example 5

SMILES CC1(C)CN(CCC11NC(=O)NC1=O)c1cc(cc2cncn12)C(F)(F)F

InChI Key InChIKey=UBMTZODMRPHSBC-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 514522   

TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514522(6,6-dimethyl-8-(7- (trifluoromethyl)imidazo[1,5- a...)
Affinity DataIC50:  3.02E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton™ X100, 20 mM ascorbate, 10 μM methylen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514522(6,6-dimethyl-8-(7- (trifluoromethyl)imidazo[1,5- a...)
Affinity DataIC50:  1.20E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton™ X100, 20 mM ascorbate, 10 μM methylen...More data for this Ligand-Target Pair