BDBM514549 6,6-dimethyl-8-(6- (trifluoromethyl)imidazo[1,5- a]pyridin-8-yl)-1,3,8- triazaspiro[4.5]decane-2,4- dione::US11096930, Example 12

SMILES CC1(C)CN(CCC11NC(=O)NC1=O)c1cc(cn2cncc12)C(F)(F)F

InChI Key InChIKey=ZOTCSZPLMLFDHA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 514549   

TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514549(6,6-dimethyl-8-(6- (trifluoromethyl)imidazo[1,5- a...)
Affinity DataIC50:  794nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton™ X100, 20 mM ascorbate, 10 μM methylen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514549(6,6-dimethyl-8-(6- (trifluoromethyl)imidazo[1,5- a...)
Affinity DataIC50:  1.82E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton™ X100, 20 mM ascorbate, 10 μM methylen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent