BDBM514722 (3S)-N-[3-(2-[[(2R)-1-hydroxypropan-2-yl]amino]-6-[(1R,6S)-3-oxabicyclo[4.1.0]heptan-6-yl]pyridin-4-yl)-4-methylphenyl]-3-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, (3S)-N-[3-(2-[[(2R)-1-hydroxypropan-2-yl]amino]-6-[(1S,6R)-3-oxabicyclo[4.1.0]heptan-6-yl]pyridin-4-yl)-4-methylphenyl]-3-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide::US11098031, Example 84::US11098031, Example 85

SMILES C[C@H](CO)Nc1cc(cc(n1)[C@]12C[C@H]1COCC2)-c1cc(NC(=O)N2CC[C@@H](CC(F)(F)F)C2)ccc1C

InChI Key InChIKey=HDQCXLYOMOMTNV-ISRZLLHTSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 514722   

TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM514722((3S)-N-[3-(2-[[(2R)-1-hydroxypropan-2-yl]amino]-6-...)
Affinity DataIC50: <10nMAssay Description:Small molecule inhibition of RAF1 kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test kinase and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM514722((3S)-N-[3-(2-[[(2R)-1-hydroxypropan-2-yl]amino]-6-...)
Affinity DataIC50: <10nMAssay Description:Small molecule inhibition of RAF1 kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test kinase and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent