BDBM515018 US11098044, Example 60::US11098044, Example 61

SMILES F[C@H]1C[C@H]1C(=O)Nc1cn2cc(ccc2n1)-c1cccc(F)c1C#N

InChI Key InChIKey=NLXGPUYLEYEZDV-DOMZBBRYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 515018   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM515018(US11098044, Example 60 | US11098044, Example 61)
Affinity DataIC50:  55nMAssay Description:c-abl: ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(p-aminoethyl ether)-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM515018(US11098044, Example 60 | US11098044, Example 61)
Affinity DataIC50:  55nMAssay Description:The LRRK2 and LRRK2 G2019S kinase assays were performed using the Adapta™ technology in ThermoFisher Scientific. This experiment was carried out acco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM515018(US11098044, Example 60 | US11098044, Example 61)
Affinity DataIC50:  55nMAssay Description:The LRRK2 and LRRK2 G2019S kinase assays were performed using the Adapta™ technology in ThermoFisher Scientific. This experiment was carried out acco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM515018(US11098044, Example 60 | US11098044, Example 61)
Affinity DataIC50: <10nMAssay Description:c-abl: ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(p-aminoethyl ether)-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM515018(US11098044, Example 60 | US11098044, Example 61)
Affinity DataIC50:  55nMAssay Description:The LRRK2 and LRRK2 G2019S kinase assays were performed using the Adapta™ technology in ThermoFisher Scientific. This experiment was carried out acco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM515018(US11098044, Example 60 | US11098044, Example 61)
Affinity DataIC50:  55nMAssay Description:The LRRK2 and LRRK2 G2019S kinase assays were performed using the Adapta™ technology in ThermoFisher Scientific. This experiment was carried out acco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent