BDBM517856 Preparation of N-(5-((4-(2-(2,2-difluoroethoxy)-4-fluoro-1-isopropyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide::US11111233, Example 64

SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cc(F)c2nc(OCC(F)F)n(C(C)C)c2c1

InChI Key InChIKey=WSVPRSUUHHPKHD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 517856   

TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Shenzhen Targetrx

US Patent
LigandPNGBDBM517856(Preparation of N-(5-((4-(2-(2,2-difluoroethoxy)-4-...)
Affinity DataIC50: <1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shenzhen Targetrx

US Patent
LigandPNGBDBM517856(Preparation of N-(5-((4-(2-(2,2-difluoroethoxy)-4-...)
Affinity DataIC50:  25nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent