BDBM521369 4-(2,2-difluoro- 1,3- benzodioxol-5- yl)-5-[4-[(3S)-1- (3- fluoropropyl)pyr- rolidin-3- yl]oxyphenyl]- 2,3-dihydro-1- benzothiepin-8- ol::US11149031, Example 193

SMILES Oc1ccc2c(SCCC(c3ccc4OC(F)(F)Oc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1

InChI Key InChIKey=UIMJJWQDDBEFIS-QHCPKHFHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521369   

TargetEstrogen receptor [298-554](Human)
Sanofi

US Patent
LigandPNGBDBM521369(4-(2,2-difluoro- 1,3- benzodioxol-5- yl)-5-[4-[(3S...)
Affinity DataIC50:  1nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetEstrogen receptor [298-554,Y537S](Human)
Sanofi

US Patent
LigandPNGBDBM521369(4-(2,2-difluoro- 1,3- benzodioxol-5- yl)-5-[4-[(3S...)
Affinity DataIC50:  20nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetEstrogen receptor [298-554,D538G](Human)
Sanofi

US Patent
LigandPNGBDBM521369(4-(2,2-difluoro- 1,3- benzodioxol-5- yl)-5-[4-[(3S...)
Affinity DataIC50:  25nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent