BDBM521420 6-(2-fluoro-4- methyl-phenyl)- 5-[2-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]oxypyrimidin- 5-yl]-8,9- dihydro-7H- benzo[7]annulen- 2-ol::US11149031, Example 244

SMILES Cc1ccc(c(F)c1)C1=C(c2cnc(O[C@H]3CCN(CCCF)C3)nc2)c2ccc(O)cc2CCC1

InChI Key InChIKey=HTQUXUFPCHDMRF-QHCPKHFHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521420   

TargetEstrogen receptor [298-554](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521420(6-(2-fluoro-4- methyl-phenyl)- 5-[2-[(3S)-1-(3- fl...)
Affinity DataIC50:  3nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [298-554,Y537S](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521420(6-(2-fluoro-4- methyl-phenyl)- 5-[2-[(3S)-1-(3- fl...)
Affinity DataIC50:  34nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [298-554,D538G](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521420(6-(2-fluoro-4- methyl-phenyl)- 5-[2-[(3S)-1-(3- fl...)
Affinity DataIC50:  67nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent