BDBM521547 Isopropyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-2-fluoro-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate::US11149049, No. 5

SMILES CC(C)OC(=O)[C@@H](C)NP(=O)(OC[C@@]1(F)O[C@](C#N)([C@H](O)[C@@H]1O)c1ccc2c(N)ncnn12)Oc1ccccc1

InChI Key InChIKey=HCAYUOOXSCDROE-ZUHPLVJWSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521547   

TargetReplicase polyprotein 1ab(HCoV-OC43)
Janssen Biopharma

US Patent
LigandPNGBDBM521547(Isopropyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f...)
Affinity DataEC50:  2.53E+4nMAssay Description:The human β-coronavirus strain OC43 was purchased from ATCC (Manassas, Va.; item numbers VR-1558 and VR-740, respectively). 24 hours prior to do...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetRous sarcoma virus integrase(RSV-Pr-C)
Janssen Biopharma

US Patent
LigandPNGBDBM521547(Isopropyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f...)
Affinity DataEC50:  2.74E+3nMAssay Description:The HeLa-derived cells containing the stable RSV replicon were cultured in DMEM containing 4500 mg/L D-glucose, L-glutamine, and 110 mg/L sodium pyru...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM521547(Isopropyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f...)
Affinity DataEC50:  7.37E+3nMAssay Description:The Dengue virus type 2 strain New Guniea C (NG-C) and the Dengue virus type 4 strain H241 were purchased from ATCC (Manassas, Va.; item numbers VR-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent