BDBM522280 US11161839, Example 10a

SMILES Cn1c2ccc(Nc3ccnc(Cl)c3C#N)cc2c(NC(C)(C)c2ncc(cn2)C2CC2)cc1=O

InChI Key InChIKey=NSEPTCJLWMVQFB-UHFFFAOYSA-N

Data  7 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 522280   

TargetB-cell lymphoma 6 protein [5-129](Homo sapiens (Human))
The Institute of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM522280(US11161839, Example 10a)
Affinity DataIC50:  29.5nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained either 1 nM (data in table 1b) or 10 nM (data in table 1a) Trx-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522280(US11161839, Example 10a)
Affinity DataIC50:  26nMAssay Description:Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522280(US11161839, Example 10a)
Affinity DataIC50:  26nMAssay Description:Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522280(US11161839, Example 10a)
Affinity DataIC50:  26nMAssay Description:Inhibition of human N-terminal thioredoxin 6-His tagged BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 pe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522280(US11161839, Example 10a)
Affinity DataKd:  234nMAssay Description:Binding affinity to human BCL6 BDB domain by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522280(US11161839, Example 10a)
Affinity DataIC50: <3nMAssay Description:Inhibition of BCOR peptide binding to human BCL6 expressed in Escherichia coli measured after 270 mins by BCOR ULight TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522280(US11161839, Example 10a)
Affinity DataIC50:  570nMAssay Description:Inhibition of human C-terminal nanoLuc-tagged BCL6 expressed in HEK293T cells co-expressing HaloTagged-SMRT using NanoBRET furimazine as substrate in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522280(US11161839, Example 10a)
Affinity DataIC50:  570nMAssay Description:Inhibition of human nanoLuc-tagged BCL6 expressed in HEK293T cells coexpressing HaloTag-SMRT using NanoBRET furimazine substrate incubated for 6 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB