BDBM522385 8-chloro-2-(cis-4-fluorocyclohexyl)-1-[(2R,4R)-2-methyltetrahydro-2H-pyran-4-yl]-1H-imidazo[-c]quinoline::US11161844, Example 1

SMILES C[C@@H]1C[C@@H](CCO1)Nc1c(NC(=O)C2CC[C@H](F)CC2)cnc2ccc(Cl)cc12

InChI Key InChIKey=RYPPKEVIABMAST-KLCSZFHISA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 522385   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522385(8-chloro-2-(cis-4-fluorocyclohexyl)-1-[(2R,4R)-2-m...)
Affinity DataIC50:  4.75nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522385(8-chloro-2-(cis-4-fluorocyclohexyl)-1-[(2R,4R)-2-m...)
Affinity DataIC50:  7.32nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent