BDBM522386 8-chloro-2-(cis-3-fluorocyclobutyl)-1-[(2R,4R)-2-methyltetrahydro-2H-pyran-4-yl]-1H-imidazo[-c]quinoline::US11161844, Example 2

SMILES C[C@@H]1C[C@@H](CCO1)n1c(nc2cnc3ccc(Cl)cc3c12)C1C[C@H](F)C1

InChI Key InChIKey=DKGKIYIUMKIJQZ-FMCMVYLNSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 522386   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522386(8-chloro-2-(cis-3-fluorocyclobutyl)-1-[(2R,4R)-2-m...)
Affinity DataIC50:  5.49nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522386(8-chloro-2-(cis-3-fluorocyclobutyl)-1-[(2R,4R)-2-m...)
Affinity DataIC50:  8.99nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent