BDBM522387 8-chloro-2-(cis-3-fluoro-3-methylcyclobutyl)-1-[(2R,4R)-2-methyl tetrahydro-2H-pyran-4-yl]-1H-imidazo[-c]quinoline::US11161844, Example 3
SMILES C[C@@H]1C[C@@H](CCO1)Nc1c(NC(=O)C2C[C@@](C)(F)C2)cnc2ccc(Cl)cc12
InChI Key InChIKey=WNBLEXLGPNQPDM-RLQJHQNESA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 522387
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Pfizer
US Patent
Pfizer
US Patent
Affinity DataIC50: 5.44nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Affinity DataIC50: 6.81nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair