BDBM522398 2-[(cis)-3-fluorocyclopentyl]-1-[(2R,4R)-2-methyltetrahydro-2H-pyran-4-yl]-1H-imidazo[-c]quinoline-8-carbonitrile, ENT 2::US11161844, Example 14

SMILES C[C@@H]1C[C@@H](CCO1)n1c(nc2cnc3ccc(cc3c12)C#N)C1CCC(F)C1

InChI Key InChIKey=VCGRRVBPZIYWRD-LHUBUQBQSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 522398   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522398(2-[(cis)-3-fluorocyclopentyl]-1-[(2R,4R)-2-methylt...)
Affinity DataIC50:  10.8nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522398(2-[(cis)-3-fluorocyclopentyl]-1-[(2R,4R)-2-methylt...)
Affinity DataIC50:  15.2nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent