BDBM522411 US11161844, Example 27::{cis-4-[8-chloro-2-(3,3-difluorocyclobutyl)-1H- imidazo[-c]quinolin-1-yl]tetrahydro-2H-pyran- 2-yl}acetonitrile, ENT 2

SMILES FC1(F)CC(C1)c1nc2cnc3ccc(Cl)cc3c2n1C1CCOC(CC#N)C1

InChI Key InChIKey=QWGYZWSTLWLTCH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 522411   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522411(US11161844, Example 27 | {cis-4-[8-chloro-2-(3,3-d...)
Affinity DataIC50:  12.2nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522411(US11161844, Example 27 | {cis-4-[8-chloro-2-(3,3-d...)
Affinity DataIC50:  12nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent