BDBM522412 US11161844, Example 28::US11161844, Example 29::{(2S,4R)-4-[8-chloro-2-(cis-4-fluorocyclohexyl)-1H-imidazo[-c]quinolin-1-yl]tetrahydro-2H-pyran-2-yl}acetonitrile

SMILES F[C@H]1CCC(CC1)c1nc2cnc3ccc(Cl)cc3c2n1C1CCO[C@H](CC#N)C1

InChI Key InChIKey=DLTAGKZYKHBRBW-XYQBIQKZSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 522412   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522412(US11161844, Example 28 | US11161844, Example 29 | ...)
Affinity DataIC50:  9.71nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522412(US11161844, Example 28 | US11161844, Example 29 | ...)
Affinity DataIC50:  4.63nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522412(US11161844, Example 28 | US11161844, Example 29 | ...)
Affinity DataIC50:  6.53nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522412(US11161844, Example 28 | US11161844, Example 29 | ...)
Affinity DataIC50:  5.12nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent