BDBM522416 2-[cis-3-fluorocyclopentyl]- 1-[(3R)-1-methylpyrrolidin- 3-yl]-1H-imidazo[- c]quinoline-8-carbonitrile, DIAST 11::US11161844, Example 32::US11161844, Example 33

SMILES CN1CC[C@H](C1)n1c(nc2cnc3ccc(cc3c12)C#N)C1CCC(F)C1

InChI Key InChIKey=UNZMETHDDKURGF-UYSNPLJNSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 522416   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522416(2-[cis-3-fluorocyclopentyl]- 1-[(3R)-1-methylpyrro...)
Affinity DataIC50:  19.6nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522416(2-[cis-3-fluorocyclopentyl]- 1-[(3R)-1-methylpyrro...)
Affinity DataIC50:  4.30nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522416(2-[cis-3-fluorocyclopentyl]- 1-[(3R)-1-methylpyrro...)
Affinity DataIC50:  6.56nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522416(2-[cis-3-fluorocyclopentyl]- 1-[(3R)-1-methylpyrro...)
Affinity DataIC50:  37.9nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent