BDBM523768 US11136312, Compound SK-I-105

SMILES COc1ccc(Cc2nnc(Cc3c[nH]c4cc(F)ccc34)n2CCCc2c[nH]cn2)cc1

InChI Key InChIKey=LYMDSJLOXOXMHN-UHFFFAOYSA-N

Data  10 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 523768   

TargetSomatostatin receptor type 4(Homo sapiens (Human))
Southern Illinois University Edwardsville

Curated by ChEMBL
LigandPNGBDBM523768(US11136312, Compound SK-I-105)
Affinity DataKi:  5.10nMAssay Description:Displacement of [125I]-Tyr-SRIF 14 from human SST4 receptor expressed in membrane measured after 90 mins by gamma counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 4(Homo sapiens (Human))
Southern Illinois University Edwardsville

Curated by ChEMBL
LigandPNGBDBM523768(US11136312, Compound SK-I-105)
Affinity DataKi:  5.13nMAssay Description:Competitive radioligand binding experiments were performed using MEMBRANE TARGET Systems (Perkin-Elmer, Boston, Mass.) for human somatostatin recepto...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 1(Homo sapiens (Human))
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523768(US11136312, Compound SK-I-105)
Affinity DataKi:  1.08E+3nMAssay Description:Competitive radioligand binding experiments were performed using MEMBRANE TARGET Systems (Perkin-Elmer, Boston, Mass.) for human somatostatin recepto...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 1(Homo sapiens (Human))
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523768(US11136312, Compound SK-I-105)
Affinity DataKi:  1.08E+3nMAssay Description:Displacement of [125I]-Tyr-SRIF 14 from SST1 receptor (unknown origin) expressed in membrane measured after 90 mins by gamma counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Southern Illinois University Edwardsville

Curated by ChEMBL
LigandPNGBDBM523768(US11136312, Compound SK-I-105)
Affinity DataKi:  5.30E+3nMAssay Description:Displacement of [125I]-Tyr-SRIF 14 from human SST2A receptor expressed in membrane measured after 90 mins by gamma counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Southern Illinois University Edwardsville

Curated by ChEMBL
LigandPNGBDBM523768(US11136312, Compound SK-I-105)
Affinity DataKi:  5.30E+3nMAssay Description:Competitive radioligand binding experiments were performed using MEMBRANE TARGET Systems (Perkin-Elmer, Boston, Mass.) for human somatostatin recepto...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 5(Homo sapiens (Human))
Southern Illinois University Edwardsville

Curated by ChEMBL
LigandPNGBDBM523768(US11136312, Compound SK-I-105)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]-Tyr-SRIF 14 from SST5 receptor (unknown origin) expressed in membrane measured after 90 mins by gamma counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 3(Homo sapiens (Human))
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523768(US11136312, Compound SK-I-105)
Affinity DataKi: >1.00E+4nMAssay Description:Competitive radioligand binding experiments were performed using MEMBRANE TARGET Systems (Perkin-Elmer, Boston, Mass.) for human somatostatin recepto...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 3(Homo sapiens (Human))
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523768(US11136312, Compound SK-I-105)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]-Tyr-SRIF 14 from SST3 receptor (unknown origin) expressed in membrane measured after 90 mins by gamma counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 5(Homo sapiens (Human))
Southern Illinois University Edwardsville

Curated by ChEMBL
LigandPNGBDBM523768(US11136312, Compound SK-I-105)
Affinity DataKi: >1.00E+4nMAssay Description:Competitive radioligand binding experiments were performed using MEMBRANE TARGET Systems (Perkin-Elmer, Boston, Mass.) for human somatostatin recepto...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 4(Homo sapiens (Human))
Southern Illinois University Edwardsville

Curated by ChEMBL
LigandPNGBDBM523768(US11136312, Compound SK-I-105)
Affinity DataEC50:  6.70nMAssay Description:Agonist activity at recombinant human SST4 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 3(Homo sapiens (Human))
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523768(US11136312, Compound SK-I-105)
Affinity DataEC50:  6.65nMAssay Description:Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent