BDBM524892 US11168095, Example 33

SMILES Cc1nn(C)c(C)c1-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3

InChI Key InChIKey=SSUGPIPKAXJZJK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 524892   

TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Biogen Ma

US Patent
LigandPNGBDBM524892(US11168095, Example 33)
Affinity DataIC50: <100nMAssay Description:Table 2: Alternatively, the protein kinase activity of the compounds described herein were tested using the ASK1/MAP3K5 assay by Reaction Biology Cor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Biogen Ma

US Patent
LigandPNGBDBM524892(US11168095, Example 33)
Affinity DataIC50: <100nMAssay Description:Table 1: Briefly, 20 μL aliquots of a 1.5× stock of ASK1, STK Substrate 3 and Assay Buffer were distributed in the wells of a white 384 well Opt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent