BDBM525421 US11174245, # I-003

SMILES Cn1cc(cn1)-c1cc(ccn1)C(=O)\N=c1/[nH]c2ccccc2n1C1CCCC1

InChI Key InChIKey=WIQWYJGDNYEQLK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 525421   

TargetEpidermal growth factor receptor [695-745,751-1022,T790M,C797S](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525421(US11174245, # I-003)
Affinity DataIC50:  9.90nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [695-1022](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525421(US11174245, # I-003)
Affinity DataIC50:  4.08E+3nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [695-1022,T790M,C797S,L858R](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525421(US11174245, # I-003)
Affinity DataIC50:  61.7nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent