BDBM525548 5-(1-(6-((3S,4S)-3-fluoro- 4-hydroxypiperidin-1- yl)pyrimidin-4-yl)-1H- indazol-6- yl)spiro[2.3]hexane-5- carbonitrile::US11174248, Example 6

SMILES O[C@H]1CCN(C[C@@H]1F)c1cc(ncn1)-n1ncc2ccc(cc12)C1(CC2(CC2)C1)C#N

InChI Key InChIKey=WHTWJSNINFWOHF-HKUYNNGSSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 525548   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM525548(5-(1-(6-((3S,4S)-3-fluoro- 4-hydroxypiperidin-1- y...)
Affinity DataIC50:  6.20nMAssay Description: Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped and phosphorylated substrate detected with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent