BDBM525854 US11174254, Compound G-15

SMILES C=CC(=O)Nc1cccc(Nc2nc3CNC(=O)c3c(Nc3ccc(cc3)N3CCOCC3)n2)c1

InChI Key InChIKey=ZVAUQFPCSPQPRD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 525854   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Yangtze River Pharmaceutical Group

US Patent
LigandPNGBDBM525854(US11174254, Compound G-15)
Affinity DataIC50:  4.27E+3nMAssay Description:The inhibitory activity of compounds to be tested on wild-type EGFR kinase (Invitrogen, PV3872) was measured by z-lyte methods.The working concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Yangtze River Pharmaceutical Group

US Patent
LigandPNGBDBM525854(US11174254, Compound G-15)
Affinity DataIC50:  52nMAssay Description:The compound was predissolved in 100% DMSO.10 mM drug stock solution was obtained by dissolution at room temperature and then gradiently diluted with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent