BDBM525910 5-chloro-4-((2-cyanobenzyl)amino)-2-fluoro-N-(thiazol-2-yl)benzenesulfonamide::US11174268, Example 17

SMILES Fc1cc(NCc2ccccc2C#N)c(Cl)cc1S(=O)(=O)Nc1nccs1

InChI Key InChIKey=URZHGUANLMQVBE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 525910   

TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525910(5-chloro-4-((2-cyanobenzyl)amino)-2-fluoro-N-(thia...)
Affinity DataIC50:  308nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525910(5-chloro-4-((2-cyanobenzyl)amino)-2-fluoro-N-(thia...)
Affinity DataIC50:  494nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525910(5-chloro-4-((2-cyanobenzyl)amino)-2-fluoro-N-(thia...)
Affinity DataIC50:  8.46E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent