BDBM525934 5-chloro-2-fluoro-N-(thiazol-2-yl)-4-((3,3,3-trifluoro-1-phenylpropyl)amino)benzenesulfonamide::US11174268, Example 41

SMILES Fc1cc(NC(CC(F)(F)F)c2ccccc2)c(Cl)cc1S(=O)(=O)Nc1nccs1

InChI Key InChIKey=IYMXTVBKMMBTML-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 525934   

TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525934(5-chloro-2-fluoro-N-(thiazol-2-yl)-4-((3,3,3-trifl...)
Affinity DataIC50:  70nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525934(5-chloro-2-fluoro-N-(thiazol-2-yl)-4-((3,3,3-trifl...)
Affinity DataIC50:  10nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525934(5-chloro-2-fluoro-N-(thiazol-2-yl)-4-((3,3,3-trifl...)
Affinity DataIC50:  31nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525934(5-chloro-2-fluoro-N-(thiazol-2-yl)-4-((3,3,3-trifl...)
Affinity DataIC50:  364nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525934(5-chloro-2-fluoro-N-(thiazol-2-yl)-4-((3,3,3-trifl...)
Affinity DataIC50:  1.18E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent