BDBM527610 US11186588, Example 83::US11186588, Example 86

SMILES COC(=O)c1ncccc1CN1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1

InChI Key InChIKey=OPAISOVMFZXKIN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 527610   

TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Ayumi Pharmaceutical

US Patent
LigandPNGBDBM527610(US11186588, Example 83 | US11186588, Example 86)
Affinity DataIC50:  95.3nMAssay Description:A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Ayumi Pharmaceutical

US Patent
LigandPNGBDBM527610(US11186588, Example 83 | US11186588, Example 86)
Affinity DataIC50:  2.82E+3nMAssay Description:A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent