BDBM527736 5-{1-(cyclopropylmethyl)-3- [2-(dimethylamino)ethyl]-2- oxo-1,3,8-triazaspiro[4.5]dec- 8-yl}-3-(1-methyl-1H- pyrazol-4-yl)pyrazine-3- carbonitrile::US11179389, Compound 1-4
SMILES CN(C)CCN1CC2(CCN(CC2)c2cnc(C#N)c(n2)-c2cnn(C)c2)N(CC2CC2)C1=O
InChI Key InChIKey=KLZSJUQYYIAVDG-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 527736
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [14-604](Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 10nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4ŚReaction...More data for this Ligand-Target Pair