BDBM527754 5-[1-(cyclopropylmethyl)-2,2- dioxido-2-thia-1,3,8- triazaspiro[4.5]dec-8-yl]-3-(1- methyl-1H-pyrazol-4- yl)pyrazine-2-carbonitrile::US11179389, Compound 1-6
SMILES Cn1cc(cn1)-c1nc(cnc1C#N)N1CCC2(CNS(=O)(=S)N2CC2CC2)CC1
InChI Key InChIKey=MLNZZZIGQUBUNQ-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 527754
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [14-604](Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 12nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4ŚReaction...More data for this Ligand-Target Pair