BDBM527759 3-(1-methyl-1H-pyrazol-4- yl)-5-[2-oxo-1-(2,2,2- trifluoroethyl)-1,3,8- triazaspiro[4.5]dec-8- yl]pyrazine-2-carbonitrile::US11179389, Compound 1-11
SMILES Cn1cc(cn1)-c1nc(cnc1C#N)N1CCC2(CNC(=O)N2CC(F)(F)F)CC1
InChI Key InChIKey=VHYFPIZHOVNOLL-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 527759
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [14-604](Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 32nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4ŚReaction...More data for this Ligand-Target Pair