BDBM528102 3-amino-N-[(2,6-difluoro-3-methoxyphenyl)methyl]-1-({4-[(2-oxopyridin-1- yl)methyl]phenyl}methyl)pyrazole-4-carboxamide::US11180484, Example 35

SMILES COc1ccc(F)c(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2N)c1F

InChI Key InChIKey=YPEAKNASZHJRPG-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 528102   

TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528102(3-amino-N-[(2,6-difluoro-3-methoxyphenyl)methyl]-1...)
Affinity DataIC50:  1.70nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528102(3-amino-N-[(2,6-difluoro-3-methoxyphenyl)methyl]-1...)
Affinity DataIC50: >4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528102(3-amino-N-[(2,6-difluoro-3-methoxyphenyl)methyl]-1...)
Affinity DataIC50: >4.00E+4nMAssay Description:FXIa inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease 1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528102(3-amino-N-[(2,6-difluoro-3-methoxyphenyl)methyl]-1...)
Affinity DataIC50: >4.00E+4nMAssay Description:Human serine protease enzymes plasmin, thrombin and trypsin were assayed for enzymatic activity using an appropriate fluorogenic substrate. Protease ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma serine protease inhibitor(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528102(3-amino-N-[(2,6-difluoro-3-methoxyphenyl)methyl]-1...)
Affinity DataIC50: >4.00E+4nMAssay Description:Human serine protease enzymes plasmin, thrombin and trypsin were assayed for enzymatic activity using an appropriate fluorogenic substrate. Protease ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528102(3-amino-N-[(2,6-difluoro-3-methoxyphenyl)methyl]-1...)
Affinity DataIC50: >4.00E+4nMAssay Description:Human serine protease enzymes plasmin, thrombin and trypsin were assayed for enzymatic activity using an appropriate fluorogenic substrate. Protease ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XII(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM528102(3-amino-N-[(2,6-difluoro-3-methoxyphenyl)methyl]-1...)
Affinity DataIC50: >4.00E+4nMAssay Description:Factor XIIa inhibitory activity in vitro was determined using standard published methods (see e.g. Shori et al., Biochem. Pharmacol., 1992, 43, 1209;...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent