BDBM530216 Preparation of 4-[(4R)-3,3-difluoro-4-methyl-1-pyrimidin-2-yl-piperidine-4-carbonyl]-3,5-dihydro-2H-pyrido[3,4-f][1,4]oxazepine-9-carbonitrile and 4-[(4S)-3,3-difluoro-4-methyl-1-pyrimidin-2-yl-piperidine-4-carbonyl]-3,5-dihydro-2H-pyrido [3,4-f][1,4]oxazepine-9-carbonitrile::US11203600, Example 297::US11203600, Example 298

SMILES FC1(F)CN(CC[C@@]1(F)C(=O)N1CCOc2c(C1)cncc2C#N)c1ncccn1

InChI Key InChIKey=MZKCUOLCZKYDMG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 530216   

TargetReceptor-interacting serine/threonine-protein kinase 1 [8-327](Human)
Denali Therapeutics

US Patent
LigandPNGBDBM530216(US11203600, Example 298 | Preparation of 4-[(4R)-3...)
Affinity DataIC50: 100nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1 [8-327](Human)
Denali Therapeutics

US Patent
LigandPNGBDBM530216(US11203600, Example 298 | Preparation of 4-[(4R)-3...)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
US Patent