BDBM530895 (R)-4-(4-(2-(1H-pyrazol- 1-yl)ethyl)piperidin-1- yl)-N1-(3-amino-2- hydroxypropyl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide::US11207312, Example 27

SMILES NC[C@@H](O)CNS(=O)(=O)c1ccc(N2CCC(CCn3cccn3)CC2)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 530895   

TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530895((R)-4-(4-(2-(1H-pyrazol- 1-yl)ethyl)piperidin-1- y...)
Affinity DataIC50:  0.0700nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530895((R)-4-(4-(2-(1H-pyrazol- 1-yl)ethyl)piperidin-1- y...)
Affinity DataIC50:  0.180nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530895((R)-4-(4-(2-(1H-pyrazol- 1-yl)ethyl)piperidin-1- y...)
Affinity DataIC50:  0.0600nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530895((R)-4-(4-(2-(1H-pyrazol- 1-yl)ethyl)piperidin-1- y...)
Affinity DataIC50:  0.0500nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent