BDBM530974 4-[4-(pyridin-2- ylmethyl)piperidin-1-yl]-N1- [(3R)-pyrrolidin-3-yl]-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide::US11207312, Example 106

SMILES NS(=O)(=O)c1c(ccc(N2CCC(Cc3ccccn3)CC2)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 530974   

TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530974(4-[4-(pyridin-2- ylmethyl)piperidin-1-yl]-N1- [(3R...)
Affinity DataIC50:  0.0600nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530974(4-[4-(pyridin-2- ylmethyl)piperidin-1-yl]-N1- [(3R...)
Affinity DataIC50:  0.460nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530974(4-[4-(pyridin-2- ylmethyl)piperidin-1-yl]-N1- [(3R...)
Affinity DataIC50:  0.100nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530974(4-[4-(pyridin-2- ylmethyl)piperidin-1-yl]-N1- [(3R...)
Affinity DataIC50:  0.120nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent