BDBM531070 (S)-N1-(1-amino-3-hydroxypropan-2-yl)-4-(4-(N-(2-aminoethyl) sulfamoyl)piperidin-1-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US11207312, Example 202

SMILES NCCNS(=O)(=O)C1CCN(CC1)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H](CN)CO

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 531070   

TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531070((S)-N1-(1-amino-3-hydroxypropan-2-yl)-4-(4-(N-(2-a...)
Affinity DataIC50:  0.440nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531070((S)-N1-(1-amino-3-hydroxypropan-2-yl)-4-(4-(N-(2-a...)
Affinity DataIC50:  1.60nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531070((S)-N1-(1-amino-3-hydroxypropan-2-yl)-4-(4-(N-(2-a...)
Affinity DataIC50:  0.0900nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531070((S)-N1-(1-amino-3-hydroxypropan-2-yl)-4-(4-(N-(2-a...)
Affinity DataIC50:  0.580nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent