BDBM532008 N-(4-{2-Amino-5-[1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]pyridin-3-yl}-3-fluorophenyl)-5-(4-methylphenyl)-4-oxo-1-(tetrahydro-2H-pyran-4-ylmethyl)-1,4-dihydropyridine-3-carboxamide methanesulfonate::US11208403, Example 85

SMILES Cc1ccc(cc1)-c1cn(CC2CCOCC2)cc(C(=O)Nc2ccc(c(F)c2)-c2cc(cnc2N)-c2cnn(c2)C2CCOCC2)c1=O

InChI Key InChIKey=YQGUQZWOHCDPTK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 532008   

TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM532008(N-(4-{2-Amino-5-[1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Affinity DataIC50:  0.400nMAssay Description:A kinase dilution solution containing 170 ng/ml AXL (the 464th to 885th amino acids of the intracellular domain of human AXL expressed as a fusion pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM532008(N-(4-{2-Amino-5-[1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Affinity DataIC50:  7nMAssay Description:A phosphorylated Axl (hereinafter, referred to as pAxl) inhibition test was conducted using a human non-small cell lung cancer-derived cell line NCI-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM532008(N-(4-{2-Amino-5-[1-(tetrahydro-2H-pyran-4-yl)-1H-p...)
Affinity DataIC50:  51nMAssay Description:A kinase dilution solution containing 20 ng/ml Mer (the 528th to 999th amino acids of the intracellular domain of human MER expressed as a fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent