BDBM533526 jm2c00120, Compound 25

SMILES CCN(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)S(=O)(=O)c1ccc(OC)c(c1)C#N

InChI Key InChIKey=ZHVNWPYRBLBLOS-WVSUBDOOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 533526   

TargetReplicase polyprotein 1ab(2019-nCoV)
University of Montpellier

LigandPNGBDBM533526(jm2c00120, Compound 25)
Affinity DataIC50:  19nMAssay Description:The transfer of tritiated methyl from [3H] SAM onto RNA substrate was monitored by filter-binding assay, performed according to the method described ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1ab(2019-nCoV)
University of Montpellier

LigandPNGBDBM533526(jm2c00120, Compound 25)
Affinity DataIC50:  19nMAssay Description:Inhibition of N-terminal 6His-tagged SARS-CoV 2 nsp14 N7-methyltransferase activity expressed in Escherichia coli C2566 using GpppAC4 synthetic RNA a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetRNA guanine-N7 methyltransferase activating subunit(Human)
University of Montpellier

LigandPNGBDBM533526(jm2c00120, Compound 25)
Affinity DataIC50:  5.28E+4nMAssay Description:The transfer of tritiated methyl from [3H] SAM onto RNA substrate was monitored by filter-binding assay, performed according to the method described ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed