BDBM534283 3 -(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl)-2-fluoro-6-methyl-N-(4,4,4-trifluoro-3-phenylbutyl)benzamide::WO2022086828, Example 11

SMILES Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NCCC(c1ccccc1)C(F)(F)F

InChI Key InChIKey=JLIIFVXHGLWALL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 534283   

TargetMixed lineage kinase domain-like protein(Homo sapiens)
Bristol-Myers Squibb

WIPO
LigandPNGBDBM534283(3 -(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-y...)
Affinity DataIC50:  1.20nMAssay Description:HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

WIPO
LigandPNGBDBM534283(3 -(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-y...)
Affinity DataIC50: >1.50E+4nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 40 nM probe and 1 nM GST-tagged PIK3C5 in complex with PIK3R1 (Invitrogen #...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

WIPO
LigandPNGBDBM534283(3 -(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-y...)
Affinity DataIC50:  5.90nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed