BDBM535155 US11236068, Example 18a::US11236068, Example 18b

SMILES C[C@H]1CN(CCN1c1nc(OC[C@@H]2CCCN2C)nc2c(F)c(c(Cl)cc12)-c1nc(N)cc(C)c1C(F)(F)F)C(=O)\C=C\CF

InChI Key InChIKey=GPOJTNHHDXMTFF-LETPOXDLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535155   

TargetGTPase KRas [G12C](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM535155(US11236068, Example 18a | US11236068, Example 18b)
Affinity DataIC50:  960nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12C](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM535155(US11236068, Example 18a | US11236068, Example 18b)
Affinity DataIC50:  8nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent