BDBM536179 (5S)-2-((4R)-4-hydroxy-1-((S)-1-(methylsulfonyl)piperidine-2-carbonyl)pyrrolidin-2-yl)-5-methyl-5-(4-(4-methylthiazol-5-yl)phenyl)-1,5-dihydro-4H-imidazol-4-one::US11242344, Example 122.1::US11242344, Example 122.2

SMILES Cc1ncsc1-c1ccc(cc1)[C@]1(C)NC(=NC1=O)C1C[C@@H](O)CN1C(=O)[C@@H]1CCCCN1S(C)(=O)=O

InChI Key InChIKey=CALGLVXMWUUKJG-CZXSMGFXSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 536179   

LigandPNGBDBM536179((5S)-2-((4R)-4-hydroxy-1-((S)-1-(methylsulfonyl)pi...)
Affinity DataIC50:  4.00E+5nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536179((5S)-2-((4R)-4-hydroxy-1-((S)-1-(methylsulfonyl)pi...)
Affinity DataKd:  1.50E+5nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536179((5S)-2-((4R)-4-hydroxy-1-((S)-1-(methylsulfonyl)pi...)
Affinity DataIC50:  3.90E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536179((5S)-2-((4R)-4-hydroxy-1-((S)-1-(methylsulfonyl)pi...)
Affinity DataIC50:  1.67E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536179((5S)-2-((4R)-4-hydroxy-1-((S)-1-(methylsulfonyl)pi...)
Affinity DataKd:  6.83E+3nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536179((5S)-2-((4R)-4-hydroxy-1-((S)-1-(methylsulfonyl)pi...)
Affinity DataIC50:  1.00E+5nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent