BDBM536232 (5S)-2-((4R)-4-Hydroxy-1-(3-methyl-2-(1-methyl-1H-pyrazol-4-yl) butanoyl) pyrrolidin-2-yl)-5-methyl-5-(4-(4-methylthiazol-5-yl) phenyl)-1,5-dihydro-4H-imidazol-4-one::US11242344, Example 110.1

SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C)c1cnn(C)c1

InChI Key InChIKey=HAPGPSOTLKJYEI-RYBWSMFQSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 536232   

LigandPNGBDBM536232((5S)-2-((4R)-4-Hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataIC50:  2.06E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536232((5S)-2-((4R)-4-Hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataIC50:  2.81E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536232((5S)-2-((4R)-4-Hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataKd:  7.42E+3nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent