BDBM536232 (5S)-2-((4R)-4-Hydroxy-1-(3-methyl-2-(1-methyl-1H-pyrazol-4-yl) butanoyl) pyrrolidin-2-yl)-5-methyl-5-(4-(4-methylthiazol-5-yl) phenyl)-1,5-dihydro-4H-imidazol-4-one::US11242344, Example 110.1
SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C)c1cnn(C)c1
InChI Key InChIKey=HAPGPSOTLKJYEI-RYBWSMFQSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 536232
TargetElongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213](Homo sapiens (Human))
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 2.06E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Affinity DataIC50: 2.81E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
TargetElongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213](Homo sapiens (Human))
Genentech
US Patent
Genentech
US Patent
Affinity DataKd: 7.42E+3nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair